PHE 540 Milestone Two Guidelines and Rubric

PHE 540 Milestone Two Guidelines and Rubric
Overview
In Milestone Two, you will continue using the Human Health Risk Assessment Template. In these steps, you will continue to evaluate the health risk of this
environmental hazard by examining its dose-response and exposure risks. This milestone will be graded with the Milestone Two Rubric and is due at the end of
Module Five.
Outcomes
ASPPH MPH Core Competencies (MPH)
Upon successful completion of the PHE 540 Final Project, you will be able to:

 	Explain the general mechanisms of toxicity in eliciting a toxic response to various environmental exposures [MPH.EHS.06]Develop a testable model of environmental insult [MPH.EHS.08]

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Prompt
(Section numbering is consistent with numbering in Final Project prompt.)
II. Human Health Risk Assessment—Part 2
You will continue to evaluate the health risk of this environmental hazard by examining its dose-response and exposure risks.
A. Hazard Identification. Please continue using the Human Health Risk Assessment Template as you complete “Part A: Hazard Identification.” Hazard
identification is the process of identifying and selecting environmental agent(s) and health effect(s) for assessment. In this step, the main question
addressed is this: Does this agent have adverse effects? To answer this question, please review the literature for information on the following:

	Explain relevant toxicokinetics, including the absorption/uptake, distribution, metabolism, and elimination processes. Provide a summary (one to two sentences) for each process. Discuss relevant toxicodynamics. Summarize the following:

o	The effects on the human body (one to three sentences);

o The mechanisms that impact human health (one to three sentences);

o	The insights into the possible effects (if known) (one to two sentences).
	Depict the Mode of Action by creating a concept map and inserting this image into the template. Your concept map will serve as a testable model of environmental insult. You may find it helpful to review Systems Thinking in the Healthcare Professions: A Guide for Educators and

Clinicians (reference this resource as necessary) while constructing the concept map. In your concept map, illustrate the sequence of key
events and processes, as follows:
o Start with interaction of an agent and a cell,
o Proceed through to the operational and anatomical changes, and
o Conclude with the resulting adverse effects on human health.
B. Dose-Response. Please continue using the Human Health Risk Assessment Template as you complete “Part B: Dose-Response.” When public health
professionals assess the dose-response, the relationship between exposure and effects is examined, answering the question: What are the health
problems at different exposures? In the field, this assessment would involve significant data collection and processing. However, for this assignment,
you will summarize the dose-response given readily available information. Using the Human Health Risk Assessment Template, address the following:
● Adverse Effects (these might include physical, mental, socioeconomic, psychosocial, or other effects). Summarize the adverse effects at
different dose levels (dose-responses). Please refer to the EPA’s website for further explanation on these components.
C. Exposure. Please continue using the Human Health Risk Assessment Template as you complete “Part C: Exposure.” When public health professionals
assess the exposure, the estimation or measurement of the magnitude, duration, and timing of human exposure to the agent of concern is a main
focus. In this field, the main questions addressed by this type of assessment includes: (1) How much of the pollutant are people exposed to during a
specific time period? or (2) How many people are exposed? In the field, this assessment would involve significant data collection and processing.
However, for this assignment, you will summarize the exposure given readily available information. Using the Human Health Risk Assessment
Template, address the following:
● Exposure pathway and exposure route. Identify the chemical’s exposure pathway and route. Please refer to the EPA’s website for further
explanation on these components.
Rubric
Guidelines for Submission: Utilize and submit the Milestone Two section of the Human Health Risk Assessment Template (linked in Module Three of your online
course).

Critical Elements	Exemplary (100%)	Proficient (90%)	Needs Improvement (70%)	Not Evident (0%)	Value
Human Health Risk Assessment: Hazard Identification: Toxicokinetics	Meets “Proficient” criteria and provides an especially insightful explanation of relevant toxicokinetics	Explains relevant toxicokinetics including the absorption/uptake, distribution, metabolism, and elimination processes, providing a summary for each process	Explains relevant toxicokinetics but the explanation fails to consider one or more processes and/or contains inaccuracies	Does not explain relevant toxicokinetics including the absorption/uptake, distribution, metabolism, and elimination processes, providing a summary for each process	18

Critical Elements	Exemplary (100%)	Proficient (90%)	Needs Improvement (70%)	Not Evident (0%)	Value
Human Health Risk Assessment: Hazard Identification: Toxicodynamics	Meets “Proficient” criteria and provides an especially insightful explanation of effects on the human body, mechanisms that impact human health, and insights into the possible effects (if known)	Explains relevant toxicodynamics and summarizes effects on the human body, mechanisms that impact human health, and insights into the possible effects (if known)	Explains relevant toxicodynamics but the explanation fails to consider either effects on the human body, mechanisms that impact human health, and insights into the possible effects (if known), or the explanation is incomplete or contains inaccuracies	Does not explain relevant toxicodynamics and summarize effects on the human body, mechanisms that impact human health, and insights into the possible effects (if known)	18
Human Health Risk Assessment: Mode of Action	Meets “Proficient” criteria and demonstrates keen insight into the interaction of agent and cell, operational and anatomical changes, and resulting adverse effects on human health	Creates a concept map that illustrates the interaction of agent and cell, operational and anatomical changes, and resulting adverse effects on human health	Creates a concept map but the concept map is incomplete or contains inaccuracies in illustrating the interaction of agent and cell, operational and anatomical changes, and resulting adverse effects on human health	Does not create a concept map that illustrates the interaction of agent and cell, operational and anatomical changes, and resulting adverse effects on human health	18
Human Health Risk Assessment: Adverse effects/ Dose-responses	Meets “Proficient” criteria and demonstrates keen insight into the adverse effects at different dose levels	Summarizes the adverse effects at different dose levels of the chemical	Summarizes the adverse effects at different dose levels of the chemical, but the summary is incomplete or contains inaccuracies	Does not summarize the adverse effects at different dose levels of the chemical	18
Human Health Risk Assessment: Exposure Pathway and Exposure Route	Meets “Proficient” criteria and demonstrates keen insight into the exposure pathway and route	Identifies the chemical’s exposure pathway and route	Identifies the chemical’s exposure pathway and route, but the identification is incomplete or contains inaccuracies	Does not identify the chemical’s exposure pathway and route	18
Articulation of Response	Submission is free of errors related to citations, grammar, spelling, syntax, and organization and is presented in a professional and easy-to read format	Submission has no major errors related to citations, grammar, spelling, syntax, or organization	Submission has major errors related to citations, grammar, spelling, syntax, or organization that negatively impact readability and articulation of main ideas	Submission has critical errors related to citations, grammar, spelling, syntax, or organization that prevent understanding of ideas	10
Total	100%