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Is there one IRB for all organizations, educational institutions and medical facilities or multiple IRB’s?

Please separate each question
Question 1 :
Is there one IRB for all organizations, educational institutions and medical facilities or multiple IRB’s?
Question 2:
What does IRB stand for? What is the role of the IRB?
Question 3:
What is the difference between internal and external validity of designs?
Question 4:
What are some weaknesses of data coupling?

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