The discussion should answer and integrate the following information:
1) On the basis of the literature and the behavioral study performed as seen in Figure 1 please provide a
rationale for deciding whether you injected apomorphine or d-amphetamine in this study.
answer: the data is not suggestive that either drug was injected due to the non-signifant data and unsuccessful
surgery to damage the SNpc if we did we would have seen a contraversive for apmorepohine and ipsiversive
for d-amphetamine…
2) Would apomorphine or d-amphetamine be the better drug to conduct a pre- and post-lesion behavioral
assay? In other words, which one should be used to test behavior before a lesion is made and after a lesion is
made?
3) Why would you recommend waiting at least seven days after a 6-OHDA lesion is made to begin
administering apomorphine and testing the rotational behavior?
4) How would you account for the drug-induced rotation after apomorphine and after d-amphetamine
treatment?
5) How would you try to cure Parkinson’s disease using the concepts that you’ve learned from this laboratory
exercise?

Sample Solution

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